Standardized methods for the production of high specific-activity zirconium-89
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چکیده
منابع مشابه
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Recent Advances in Zirconium-89 Chelator Development.
The interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown considerably over the last decade due to its standardized production, long half-life of 78.2 h, favorable decay characteristics for positron emission tomography (PET) imaging and its successful use in a variety of clinical and preclinical applications. However, to be utilized effectively in PET applications it mus...
متن کاملEvaluation of macrocyclic hydroxyisophthalamide ligands as chelators for zirconium-89
The development of bifunctional chelators (BFCs) for zirconium-89 immuno-PET applications is an area of active research. Herein we report the synthesis and evaluation of octadentate hydroxyisophthalamide ligands (1 and 2) as zirconium-89 chelators. While both radiometal complexes could be prepared quantitatively and with excellent specific activity, preparation of 89Zr-1 required elevated tempe...
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ژورنال
عنوان ژورنال: Nuclear Medicine and Biology
سال: 2009
ISSN: 0969-8051
DOI: 10.1016/j.nucmedbio.2009.05.007